dc.contributor.author |
Silveira, Jussara Maria |
|
dc.contributor.author |
Santos, Andre Ferreira dos |
|
dc.contributor.author |
Martinez, Ana Maria Blanco |
|
dc.contributor.author |
Góes, Lívia Ramos |
|
dc.contributor.author |
Sassi, Raul Andrés Mendonza |
|
dc.contributor.author |
Muniz, Claudia Priscila Ramos |
|
dc.contributor.author |
Tupinambás, Unaí |
|
dc.contributor.author |
Soares, Marcelo Alves |
|
dc.contributor.author |
Greco, Dirceu Bartolomeu |
|
dc.date.accessioned |
2012-11-20T16:47:19Z |
|
dc.date.available |
2012-11-20T16:47:19Z |
|
dc.date.issued |
2012 |
|
dc.identifier.citation |
SILVEIRA, Jussara Maria et al. Heterosexual transmission of human immunodeficiency virus type 1 subtype C in Southern Brazil. Journal of Clinical Virology, v. 54, p. 36-41, 2012. Disponível em:<http://ac.els-cdn.com/S1386653212000236/1-s2.0-S1386653212000236-main.pdf?_tid=4f6a0256-3331-11e2-a7f4-00000aab0f26&acdnat=1353429945_5a0385ef19897557c8230ed1d1b8667f>. Acesso em: 24 set. 2012. |
pt_BR |
dc.identifier.uri |
http://repositorio.furg.br/handle/1/2801 |
|
dc.description.abstract |
Background: Human immunodeficiency virus type 1 (HIV-1) subtype B predominates in Brazil, but in the southern region subtype C is the most frequent, followed by subtypes B, F1 and recombinant forms. In southern Brazil, these subtypes co-circulate in subjects with homogeneous demographic and clinical features, enabling a better understanding of the role of HIV-1 subtypes on the characteristics of infection.
Objectives: To evaluate the prevalence of different HIV-1 subtypes in subjects with recent diagnosis for HIV infection in the extreme south of Brazil, and to study their association with demographic, behavioral,
clinical and laboratorial characteristics.
Study design: We have determined the genetic sequence of viral protease and reverse transcriptase (polymerase, connection and RNase H domains) isolated from studied subjects. Viral subtype was inferred by
comparison with reference HIV sequences, and recombination was determined with Simplot analysis. The association of HIV-1 subtypes with studied characteristics was evaluated by chi-square, Fisher’s exact, Student’s t and Kruskal–Wallis tests. Results: Two hundred and forty-five HIV isolates were molecularly characterized, and the association with variables was studied for 233 (95.1%) patients. Of those, 46.8% followed AIDS defining criteria. HIV-1C
was responsible for 56.3% of infections, and was associated with heterosexual transmission (p = 0.001) and with higher CD4+ T-cell counts (p = 0.02). Conclusions: The molecular epidemiology of HIV-1 in the southernmost Brazil is currently steady with
predominance of HIV-1C. This is the first study showing a robust association of the infection by this subtype and heterosexual transmission in the state of Rio Grande do Sul, Brazil. |
pt_BR |
dc.language.iso |
eng |
pt_BR |
dc.rights |
restrict access |
pt_BR |
dc.subject |
HIV-1 |
pt_BR |
dc.subject |
Subtype C |
pt_BR |
dc.subject |
Molecular epidemiology |
pt_BR |
dc.subject |
Heterosexual transmission |
pt_BR |
dc.subject |
Brazil |
pt_BR |
dc.title |
Heterosexual transmission of human immunodeficiency virus type 1 subtype c in Southern Brazil |
pt_BR |
dc.type |
article |
pt_BR |