Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of mycobacterium tuberculosis
Carneiro, Paula Fernandes; Pinto, Maria do Carmo Freire Ribeiro; Coelho, Tatiane Silveira; Cavalcanti, Bruno Coêlho; Pessoa, Cláudia; Simone, Carlos Alberto de; Nunes, Isabelle Karine da Costa; Oliveira, Nathália Milanez de; Almeida, Renata Gomes de; Pinto, Antonio Ventura; Moura, Kelly Cristina Gallan de; Pedro, Eduardo Almeida da; Silva Júnior, Eufrânio Nunes da
Abstract:
Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.