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dc.contributor.author Schmidt, Bruno Mariano da Silva
dc.contributor.author Rezende-Neto, João Batista de
dc.contributor.author Andrade, Marcus Vinicius
dc.contributor.author Winter, Philippe Chaves
dc.contributor.author Carvalho Júnior, Mário Gissoni de
dc.contributor.author Lisboa, Thiago Assis
dc.contributor.author Rizoli, Sandro
dc.contributor.author Cunha-Melo, Jose Renan
dc.date.accessioned 2017-09-07T17:13:09Z
dc.date.available 2017-09-07T17:13:09Z
dc.date.issued 2012
dc.identifier.citation SCHMIDT, Bruno Mariano da Silva et al. Permissive hypotension does not reduce regional organ perfusion compared to normotensive resuscitation: animal study with fluorescent microspheres. World Journal of Emergency Surgery, v.7, n.1, p. 1-10, 2012. Disponível em: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424975/pdf/1749-7922-7-S1-S9.pdf> Acesso em: 14 dez. 2016. pt_BR
dc.identifier.uri http://repositorio.furg.br/handle/1/7561
dc.description.abstract Introduction: The objective of this study was to investigate regional organ perfusion acutely following uncontrolled hemorrhage in an animal model that simulates a penetrating vascular injury and accounts for prehospital times in urban trauma. We set forth to determine if hypotensive resuscitation (permissive hypotension) would result in equivalent organ perfusion compared to normotensive resuscitation. Methods: Twenty four (n=24) male rats randomized to 4 groups: Sham, No Fluid (NF), Permissive Hypotension (PH) (60% of baseline mean arterial pressure - MAP), Normotensive Resuscitation (NBP). Uncontrolled hemorrhage caused by a standardised injury to the abdominal aorta; MAP was monitored continuously and lactated Ringer’s was infused. Fluorimeter readings of regional blood flow of the brain, heart, lung, kidney, liver, and bowel were obtained at baseline and 85 minutes after hemorrhage, as well as, cardiac output, lactic acid, and laboratory tests; intra-abdominal blood loss was assessed. Analysis of variance was used for comparison. Results: Intra-abdominal blood loss was higher in NBP group, as well as, lower hematocrit and hemoglobin levels. No statistical differences in perfusion of any organ between PH and NBP groups. No statistical difference in cardiac output between PH and NBP groups, as well as, in lactic acid levels between PH and NBP. NF group had significantly higher lactic acidosis and had significantly lower organ perfusion. Conclusions: Hypotensive resuscitation causes less intra-abdominal bleeding than normotensive resuscitation and concurrently maintains equivalent organ perfusion. No fluid resuscitation reduces intra-abdominal bleeding but also significantly reduces organ perfusion. pt_BR
dc.language.iso por pt_BR
dc.rights open access pt_BR
dc.title Permissive hypotension does not reduce regional organ perfusion compared to normotensive resuscitation: animal study with fluorescent microspheres pt_BR
dc.type article pt_BR


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