Show simple item record Rosa, Carlos Eduardo da Figueiredo, Marcio de Azevedo Lanes, Carlos Frederico Ceccon Almeida, Daniela Volcan Monserrat, José María Marins, Luis Fernando Fernandes 2011-10-23T23:28:12Z 2011-10-23T23:28:12Z 2008
dc.identifier.citation ROSA, Carlos Eduardo da et. al. Metabolic rate and reactive oxygen species production in different genotypes of GH-transgenic zebrafish. Comparative Biochemistry and Physiology. B, Biochemistry & Molecular Biology , v. 149, p. 209-214, 2008. Disponível em: <>. Acesso em: 26 jun. 2011. pt_BR
dc.identifier.issn 1096-4959
dc.description.abstract Growth hormone overexpression increases growth and consequently increases the metabolic rate in fishes. Therefore, the objective of this study was to evaluate the effects of growth hormone overexpression in zebrafish Danio rerio in terms of growth, oxygen consumption, reactive oxygen species production, lipid hydroperoxide content, antioxidant enzyme activity and glutamate-cysteine ligase catalytic subunit gene expression. The employed models were wild type and transgenic (hemizygous and homozygous) zebrafish expressing the Odonthestes argentinensis growth hormone gene directed by the Cyprinus carpio beta-actin promoter. Higher growth parameters were observed in the hemizygous group. The homozygous group possessed higher oxygen consumption and reactive oxygen species production. Growth hormone transgenesis causes a decrease in glutamate-cysteine ligase catalytic subunit expression, an enzyme responsible for glutathione synthesis. Although the lipid hydroperoxide content was similar between groups, we demonstrate that growth hormone overexpression has the potential to generate oxidative stress in fishes. pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access pt_BR
dc.subject Metabolic rate pt_BR
dc.subject reactive oxygen pt_BR
dc.subject species pt_BR
dc.subject genotypes pt_BR
dc.subject GH-transgenic zebrafish pt_BR
dc.title Metabolic rate and reactive oxygen species production in different genotypes of GH-transgenic zebrafish pt_BR
dc.type article pt_BR

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