Show simple item record Aguiar, Rosiane Borba de Dickel, Odila Eli Cunha, Raquel Wigg Monserrat, José María Barros, Daniela Marti Martínez, Pablo Elías 2011-11-02T22:53:28Z 2011-11-02T22:53:28Z 2006
dc.identifier.citation AGUIAR, Rosiane Barbosa et al. Estradiol valerate and tibolone: effects on memory.Pharmacology, Biochemistry and Behavior, v. 8, p. 689-696, 2006. Disponível em:<>. Acesso em: 21 ago. 2011. pt_BR
dc.identifier.issn 0091-3057
dc.description.abstract This study investigated the effects of estradiol valerate (EV) and tibolone (TB) treatments on some memory parameters of ovariectomized young (2 months), adult (8 months)and old (20 months) female rats. A Sham-operated group was used as control and the animals were treated daily, by oral gavage,with saline (Sham and placebo NR group),EV (0.3 mg/kg) or TB (0.5 or 1 mg/kg, TB1 and TB2, respectively). In stepdown inhibitory avoidance task, the latency of old TB2-treated females in the short-term test was significantly inferior (pb0.05), compared to TB2 adults. In the elevated plus maze, adult NR females spent significantly less time (pb0.05) in the open arms as compared with EVand TB2-treated animals. Additionally, adult TB2-treated females spent significantly less time in the closed arms compared to Sham, NR and TB1 groups. Finally,in the water maze retention test, young TB1-treated animals performed worse when compared to Sham, EV and TB2 females. In the old animals, EV treatment hampered subject performance as compared to all other treatments. Taken together, these results indicate that ovarian hormones differently affect female memory in an age-dependent manner. pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access pt_BR
dc.subject Ovarian steroids pt_BR
dc.subject Memory pt_BR
dc.subject Tibolone pt_BR
dc.subject Estradiol valerate pt_BR
dc.subject Ovariectomy pt_BR
dc.subject Behavior pt_BR
dc.title Estradiol valerate and tibolone: effects on memory pt_BR
dc.type article pt_BR

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