Show simple item record Bianchini, Adalto Monserrat, José María 2010-10-07T01:30:46Z 2010-10-07T01:30:46Z 2007
dc.identifier.citation BIANCHINI, A. ; MONSERRAT, J. M . Effects of methyl parathion on Chasmagnathus granulatus hepatopancreas: Protective role of Sesamol. Ecotoxicology and Environmental Safety, Holanda, v. 67, p. 100-108, 2007. pt_BR
dc.identifier.issn 0147-6513
dc.description.abstract The protective role of sesamol, an inhibitor of the mixed function oxygenase (MFO) system, against histopathological effects of methyl parathion in the hepatopancreas of the estuarine crab, Chasmagnathus granulatus, was studied. Exposure (72 h) to a sublethal dose (0.05 mg/kg/day; 10% of 72 h-LD50) of injected methyl parathion increased the percentage of damaged hepatopancreatic tubules. Presence of melanin-like deposits in the connective tissue between hepatopancreatic tubules was also observed. Antioxidant enzyme activities (catalase and glutathione S-transferase) and lipid peroxidation (LPO) levels were also increased in hepatopancreas of crabs injected with methyl parathion. Pretreatment with sesamol (0.85 mg/kg/day) significantly protected against all these effects. These findings suggest that the hepatopancreatic damages induced by methyl parathion are due to LPO of hepatopancreatocytes membranes, as a consequence of the oxidative stress generated after methyl parathion oxidative biotransformation mediated by the MFO system. pt_BR
dc.language.iso eng pt_BR
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dc.subject Chasmagnathus granulatus pt_BR
dc.subject Crab pt_BR
dc.subject Hepatopancreas pt_BR
dc.subject Histopathology pt_BR
dc.subject Methyl parathion pt_BR
dc.subject Oxidative stress pt_BR
dc.title Effects of methyl parathion on Chasmagnathus granulates hepatopancreas: Protective role of Sesamol pt_BR
dc.type article pt_BR

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