Anthelmintics used for intestinal helminthiasis treatment are generally effective; however, their effectiveness in tissue parasitosis (i.e. visceral toxocariasis) is moderate. The aim of this study was to evaluate the in ...

Tuberculosis remains a serious public health problem, with nine million cases being reported annually. Treatment with antibiotics is the most effective mechanism to control this disease, although the increase in cases ...

As micobactérias não-tuberculosas são espécies ambientais com crescente relevância clínica, por sua relação com diversos tipos de infecções. Geralmente, apresentam maior resistência intrínseca aos antimicobacterianos ...

A tuberculose (TB) é uma doença infecciosa com uma incidência mundial estimada de 8,8 milhões de casos. Considerando o aumento no número de casos por cepas multidrogarresistente (MDR-TB) e o reduzido arsenal terapêutico, ...

Justificativa e Objetivos: O estudo objetivou a avaliação da atividade antibacteriana de extratos brutos e frações de Ibicella lutea, na inibição do crescimento de Staphylococcus aureus, avaliando a combinação destes ...

Este trabalho empregou ferramentas de bioinformática para estudar in silico o mecanismo de transporte da bomba de efluxo multidroga AcrB. Essa bomba faz parte do sistema de efluxo da bactéria gram-negativa Escherichia coli ...

When bacteria develop drug-resistant mutations, there is often an associated biological cost; however, some strains can exhibit low- or no-cost mutations. In the present study, a quantitative resazurin reduction assay ...

Introduction: Helicobacter pylori infection is associated with gastro-duodenal diseases. Genes related to pathogenicity have been described for H. pylori and some of them appear to be associated with more severe clinical ...

A major threat to tuberculosis (TB) control programs is the emergence of drug resistant Mycobacterium tuberculosis strains that cause TB that cannot be cured by standard anti-TB drug regimens. Because few data exist on ...

The Mycobacterium bovis P55 gene, located downstream from the gene that encodes the immunogenic lipoprotein P27, has been characterized. The gene was identical to the open reading frame of the Rv1410c gene in the genome ...

Genotyping tools have been widely used to study the occurrence of outbreaks and to identify the patterns of transmission of Mycobacterium tuberculosis strains. The clonal diversity of 65 clinical isolates of M. tuberculosis ...

Tuberculosis remains as a serious infection disease of worldwide distribution, with high morbidity and mortality, mainly in low socio-economic condition countries. The state of emergency of tuberculosis caused by the ...

A new one-pot strategy for the synthesis of a series of new N-substituted 3-trifluoroacetyl pyrroles is presented. These compounds were obtained by the reaction of 3-trifluoroacetyl-4,5- dihydrofuran with primary amines, ...

Background: Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of Mycobacterium tuberculosis. A few studies with limited ...

CagA of Helicobacter pylori undergoes tyrosine phosphorylation in a region containing differing numbers of repeat sequences (EPIYAs), which can result in a modulation of the inflammatory response. This study investigated ...

Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members ...

Bovine tuberculosis (BTB) remains an important economic and zoonotic problem in Latin America. Traditionally, the fight against BTB is initiated by the implementation of routine diagnostic tests for certification of free ...

Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination ...

Micobactérias do complexo Mycobacterium avium (CMA) são responsáveis por diversas infecções, principalmente pulmonares. Mundialmente distribuído, membros do CMA apresentam altas taxas de resistência aos antimicrobianos ...