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dc.contributor.author Groll, Andrea Von
dc.contributor.author Martin, Anandi
dc.contributor.author Jureen, Pontus
dc.contributor.author Hoffner, Sven
dc.contributor.author Vandamme, Peter
dc.contributor.author Portaels, Françoise
dc.contributor.author Palomino, Juan Carlos
dc.contributor.author Silva, Pedro Eduardo Almeida da
dc.date.accessioned 2012-09-26T23:32:37Z
dc.date.available 2012-09-26T23:32:37Z
dc.date.issued 2009
dc.identifier.citation GROLL, Andrea Von et al. Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb. Antimicrobial Agents and Chemotherapy, v. 53, n. 10, p. 4498-4500, 2009. Disponível em: <http://aac.asm.org/content/53/10/4498.full.pdf+html>. Acesso em: 18 set. 2012. pt_BR
dc.identifier.uri http://repositorio.furg.br/handle/1/2593
dc.description.abstract This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs were determined by the resazurin microtiter assay. Forty strains shared the same resistance results for the three fluoroquinolones. However, one strain, with an Asn-533 3 Thr mutation in gyrB, was susceptible to ofloxacin but resistant to moxifloxacin and gatifloxacin. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.title Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb pt_BR
dc.type article pt_BR
dc.identifier.doi 10.1128/AAC.00287-09 pt_BR


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