Atividade inibitória do óleo essencial de orégano em fungos de importância médica e veterinária

Cleff, Marlete Brum; Meinerz, Ana Raquel Mano; Faria, Renata Osório de; Xavier, Melissa Orzechowski; Santin, Rosema; Nascente, Patrícia da Silva; Rodrigues, Maria Regina Alves; Meireles, Mario Carlos Araujo


The in vitro activity of Origanum vulgare essential oil against fungal isolates was evaluated. A total of 27 clinical isolates were used, including: C. albicans, S. schenckii, M. pachydermatis, Aspergillus flavus, and A. fumigatus. Microdilution in broth technique (NCCLS M27-A2 and M-38) was used and susceptibility was expressed as Minimum Inhibitory Concentration (MIC). Essential oil was obtained by hydrodistillation in Clevenger and analyzed by gas chromatography, showing the presence of 4-terpineol, alpha-terpineol, 4-terpinene, thymol and carvacrol, as the main compounds. Origanum oil MIC for C. albicans varied from 125 to 500μL/mL; for S. schenckii, from 250 to 500μL/mL; for M. pachydermatis, from 15 to 30μL/mL; and for Aspergillus, from 30 to 60L/mL. Isolates sensitivity showed to the origanum oil stimulates the accomplishment of new studies, including in vivo tests, contributing to the search of alternative treatments to mycosis.

Show full item record


Files in this item

This item appears in the following Collection(s)


  • FAMED – Artigos publicados em periódicos