Show simple item record Vianna, Mônica Ryff Moreira Roca Izquierdo, Luciana Adriana Barros, Daniela Marti Souza, Márcia Maria de Rodrigues, Carla Gonçalves Sant´Anna, Márcia Kauer Medina, Jorge Horacio Izquierdo, Ivan Antônio 2012-11-29T12:32:52Z 2012-11-29T12:32:52Z 2001
dc.identifier.citation VIANNA, Mônica Ryff Moreira Roca et al. Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning. Brazilian Journal of Medical and Biological Research, v. 34, p. 233-240, 2001. Disponível em: <>. Acesso em: 22 nov. 2012. pt_BR
dc.identifier.issn 0100-879
dc.description.abstract Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus or the entorhinal cortex were submitted to either a one-trial inhibitory avoidance task, or to 5 min of habituation to an open field. Immediately after training, they received intrahippocampal or intraentorhinal 0.5-µl infusions of saline, of a vehicle (2% dimethylsulfoxide in saline), of the glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphono pentanoic acid (AP5), of the protein kinase A inhibitor Rp-cAMPs (0.5 µg/side), of the calcium-calmodulin protein kinase II inhibitor KN-62, of the dopaminergic D1 antagonist SCH23390, or of the mitogen-activated protein kinase kinase inhibitor PD098059. Animals were tested in each task 24 h after training. Intrahippocampal KN-62 was amnestic for habituation; none of the other treatments had any effect on the retention of this task. In contrast, all of them strongly affected memory of the avoidance task. Intrahippocampal Rp-cAMPs, KN-62 and AP5, and intraentorhinal Rp-cAMPs, KN-62, PD098059 and SCH23390 caused retrograde amnesia. In view of the known actions of the treatments used, the present findings point to important biochemical differences in memory consolidation processes of the two tasks. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.subject Habituation learning pt_BR
dc.subject One-trial avoidance pt_BR
dc.subject Memory consolidation pt_BR
dc.subject Pharmacology of memory consolidation pt_BR
dc.subject Hippocampus pt_BR
dc.subject Entorhinal cortex pt_BR
dc.title Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning pt_BR
dc.type article pt_BR
dc.identifier.doi pt_BR

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