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dc.contributor.author D'Oca, Caroline Da Ros Montes
dc.contributor.author Coelho, Tatiane Silveira
dc.contributor.author Marinho, Tamara Germani
dc.contributor.author Hack, Carolina Rosa Lopes
dc.contributor.author Duarte, Rodrigo da Costa
dc.contributor.author Silva, Pedro Eduardo Almeida da
dc.contributor.author D'Oca, Marcelo Gonçalves Montes
dc.date.accessioned 2013-08-09T19:50:02Z
dc.date.available 2013-08-09T19:50:02Z
dc.date.issued 2010
dc.identifier.citation D’OCA, Caroline da Ros Montes et al. Synthesis and antituberculosis activity of new fatty acid amides. Bioorganic & Medicinal Chemistry Letters, v. 20, p. 5255-5257, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0960894X10009364>. Acesso em: 17 set. 2012. pt_BR
dc.identifier.uri http://repositorio.furg.br/handle/1/3668
dc.description.abstract This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 lg/mL for resistance strains. pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access pt_BR
dc.subject Mycobacterium tuberculosis pt_BR
dc.subject Fatty acid amides pt_BR
dc.subject Ricinoleic acid pt_BR
dc.subject FAMEs pt_BR
dc.title Synthesis and antituberculosis activity of new fatty acid amides pt_BR
dc.type article pt_BR


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