Show simple item record Tortelli, Vanessa Pereira Colares, Elton Pinto Robaldo, Ricardo Berteaux Nery, Luiz Eduardo Maia Pinho, Grasiela Lopes Leães Bianchini, Adalto Monserrat, José María 2011-01-12T21:04:53Z 2011-01-12T21:04:53Z 2006
dc.identifier.citation TORTELLI, V. et al. Importance of cholinesterase kinetic parameters in environmental monitoring using estuarine fish. Chemosphere, [S.l.], v. 65, p. 560–566, 2006. Disponível em: <>. Acesso em: 12 jan. 2011. pt_BR
dc.identifier.issn 0045-6535
dc.description.abstract The aim of the present study was to determine the kinetic parameters and cholinesterase (ChE) activity in two teleost fish, the White mouth croaker Micropogonias furnieri (Scianidae) and the Madamango sea catfish Cathorops spixii (Ariidae), to verify their suitability as sentinel species of aquatic pollution by anticholinergic compounds. Individuals of each species were captured in one reference and one polluted site in the Southern Brazilian coast. Brain tissue was used as enzyme source. Inhibition kinetic parameters indicated that ChE from C. spixii collected at the reference site showed more affinity (Ka) for eserine that from those collected at the polluted site. The opposite was observed for the carbamylation constants (Kc). Thus, similar inhibition constants (Ki) were observed. M. furnieri brain showed an extremely low sensitivity to in vitro inhibition by eserine, indicating that it is not a suitable biomarker to be employed in environmental monitoring of anticholinergic compounds. Results from the present study also point to the need for considering kinetic analysis when cholinesterase activity is employed as a biomarker. pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access
dc.subject Biomarkers pt_BR
dc.subject Cholinesterase pt_BR
dc.subject Eserine pt_BR
dc.subject Fish pt_BR
dc.subject Kinetic parameters pt_BR
dc.subject Estuaries pt_BR
dc.title Importance of cholinesterase kinetic parameters in environmental monitoring using estuarine fish pt_BR
dc.type article pt_BR

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