Show simple item record Castro, Micheli Rosa de Lima, Juliane Ventura Freitas, Diana Paula Salomão de Valente, Roberto de Souza Dummer, Natália Seus Aguiar, Rosiane Borba de Santos, Luciane Cougo dos Marins, Luis Fernando Fernandes Monserrat, Laura Alicia Geracitano Monserrat, José María Barros, Daniela Marti 2011-01-17T19:18:01Z 2011-01-17T19:18:01Z 2009
dc.identifier.citation CASTRO, M. R. et al. Behavioral and neurotoxic effects of arsenic exposure in zebrafish (Danio rerio, Teleostei: Cyprinidae). Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, v. 150, p. 337-342, 2009. Disponível em: <>. Acesso em: 15 jan. 2011. pt_BR
dc.identifier.issn 1532-0456
dc.description.abstract This study investigated the passive avoidance conditioning in zebrafish (Danio rerio). An instrument was developed for measuring escape responses triggered by a conditioned stimulus. This system allowed quantification of latency of crossing from a light to a dark zone. Zebrafish were trained to swim from an illuminated to a dark compartment, where they received a body shock (training session). The proposed methodology was efficient for evaluation of working, short, and long-term memory formation of an aquatic animal model. The possibility of employing memory measurements in toxicity tests, in order to obtain an ecologically meaningful biomarker response, was also analyzed. In this experiment, immediately after the training session, fish were exposed to three arsenic (AsV) concentrations. After the test session, the brain was removed for biochemical analyses. A control group was kept in tap water. After exposure, animals were submitted to a one-trial inhibitory avoidance test for measurement of long-term memory (LTM). Results from behavioral and biochemical analyses showed that the three AsV concentrations impaired LTM (pb0.05) and increased protein oxidation, which suggests an amnesic and pro-oxidant effect of AsV. Evaluation of behavior parameters in aquatic models is an important complement in studies concerning the environmental impact of chemical substances. pt_BR
dc.language.iso eng pt_BR
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dc.subject Memory pt_BR
dc.subject Arsenic pt_BR
dc.subject Zebrafish pt_BR
dc.subject Behavioral pt_BR
dc.subject Inhibitory avoidance pt_BR
dc.title Behavioral and neurotoxic effects of arsenic exposure in zebrafish (Danio rerio, Teleostei: Cyprinidae). pt_BR
dc.type article pt_BR

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