Investigation of the anti-inflammatory and analgesic effects from an extract of Aplysina caissara, a marine sponge

Azevedo, Luciana Gutterres de; Peraza, Gianni Goulart; Lerner, Cléa Beatriz; Soares, Andréa Dalben; Murcia, Nícolas Pereira; Baisch, Ana Luiza Muccillo


A variety of biologically active compounds with pharmacological applications has been reported to occur in marine sponges. The present study was undertaken to provide a set of data about an extract from Aplysina caissara, a Brazilian marine sponge. The antinociceptive and anti-inflammatory effects were investigated against different experimental models in mice. When evaluated against writhing test intraperitoneally (60 and 90 mg/kg), the extract significantly inhibited abdominal constriction by 33.7% and 41.4% respectively. In the formalin test (60 and 90 mg/kg), the extract of sponge inhibited 43.6% and 51.6% in the first phase and 98.2% and 97.2% in the second phase respectively. When evaluated against the hot plate test, both doses demonstrated activity. An increase in the hot plate latency was observed after 60 min. The anti-inflammatory effect was evaluated by formalininduced mice paw edema. Extract from A. caissara (60 and 90 mg/kg) significantly reduced hind paw swelling. Mortality increased with increasing doses, with LD50 of 212.2 mg/kg for intraperitoneal administration. These results demonstrated that the extract of the marine sponge A. caissara possesses antinociceptive and antiedematogenic effects.

Show full item record


Files in this item

This item appears in the following Collection(s)


  • ICB - Artigos publicados em periódicos