Show simple item record Silva, Pedro Eduardo Almeida da Palomino, Juan Carlos 2014-01-17T17:26:18Z 2014-01-17T17:26:18Z 2011
dc.identifier.citation SILVA, Pedro Eduardo Almeida da; PALOMINO, Juan Carlos. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs . Journal of Antimicrobial Chemotherapy, v. 66, n. 7, p. 1417-1430, 2011. Disponível em: <>. Acesso em: 23 dez. 2013. pt_BR
dc.identifier.issn 0305-7453
dc.description.abstract Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared as a global emergency in 1993 by the WHO, its control is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. More recently, severe forms of drug resistance such as extensively drug-resistant (XDR) TB have been described. After the discovery of several drugs with anti-TB activity, multidrug therapy became fundamental for control of the disease. Major advances in molecular biology and the availability of new information generated after sequencing the genome of Mycobacterium tuberculosis increased our knowledge of the mechanisms of resistance to the main anti-TB drugs. Better knowledge of the mechanisms of drug resistance in TB and the molecular mechanisms involved will help us to improve current techniques for rapid detection and will also stimulate the exploration of new targets for drug activity and drug development. This article presents an updated review of the mechanisms and molecular basis of drug resistance in M. tuberculosis. It also comments on the several gaps in our current knowledge of the molecular mechanisms of drug resistance to the main classical and new anti-TB drugs and briefly discusses some implications of the development of drug resistance and fitness, transmission and pathogenicity of M. tuberculosis. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.subject TB pt_BR
dc.subject MDR pt_BR
dc.subject XDR pt_BR
dc.subject quinolones pt_BR
dc.subject fitness pt_BR
dc.title Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs pt_BR
dc.type article pt_BR
dc.identifier.doi 10.1093/jac/dkr173 pt_BR

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