Show simple item record Silva, Naylê Maria Oliveira da Germano, Fabiana Nunes Sassi, Raúl Andrés Mendoza Abreu, Hector Nicolas Seuánez Soares, Marcelo Alves Martinez, Ana Maria Barral de 2014-02-22T21:21:03Z 2014-02-22T21:21:03Z 2013
dc.identifier.citation SILVA, Naylê Maria Oliveira da. et al. Evidence of association between hepatitis C virus genotype 2b and nosocomial transmissions in hemodialysis centers from southern Brazil. Virology Journal, v. 10, p. 167-173, may 2013. Disponível em: <>. Acesso em: 24 jan. 2014. pt_BR
dc.identifier.issn 1743-422X
dc.description.abstract Background: Hepatitis C virus infection is a serious public health problem. Hemodialysis is considered one of the main risk factors of HCV infection, due to several invasive medical procedures and potential nosocomial transmission that patients with chronic renal failure (CRF) are continuously submitted. The aims of this study were to determine the prevalence of HCV and its genotypes in patients with CRF in hemodialysis units in southern Brazil. Methods: Demographic data and risk factors for HCV transmission were collected and analyzed. These data were obtained from patients undergoing hemodialysis treatment from January 2009 to August 2010, on two dialysis units of Rio Grande, southern Brazil. Genotyping was carried out by sequencing analysis of HCV NS5b, core-E1 junction and 5′UTR genomic regions. Results: One hundred fifty-nine patients under regular hemodialysis treatment were studied. HCV prevalence was 23.3%. HCV-infected patients had been on dialysis treatment for 91.9 months, a more prolonged period compared to HCV-negative patients (p = 0.001). While HCV genotypes 1b and 3a were identified as the most frequent strains, a surprisingly high proportion of genotype 2b was observed among patients in one of the dialysis centers compared to the general HCV-infected population of the same area. Hemodialysis treatment exposure time and healthcare working were associated with HCV infection. Conclusions: Besides the efforts to minimize nosocomial transmission of HCV, some events of transmission are still evidenced in dialysis units. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.subject Hepatitis C virus pt_BR
dc.subject Genotype pt_BR
dc.subject Hemodialysis pt_BR
dc.subject Nosocomial infection pt_BR
dc.subject Southern Brazil pt_BR
dc.title Evidence of association between hepatitis C virus genotype 2b and nosocomial transmissions in hemodialysis centers from southern Brazil pt_BR
dc.type article pt_BR

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