Show simple item record Weber, Gisele Eva Bruch Bosco, Lidiane Dal Gonçalves, Carla Onara Ferreirra Santos, Adelina Pinheiro Leite, Cristiano Fantini Furtado, Clascidia Aparecida Parfitt, Gustavo Morrone Barbat Peixoto, Carolina da Silva Romano, Luis Alberto Vaz, Bernardo dos Santos Barros, Daniela Marti 2016-01-18T23:02:04Z 2016-01-18T23:02:04Z 2014
dc.identifier.citation WEBER, Gisele Eva Bruch et al. Biodistribution and toxicological study of PEGylated single-wall carbon nanotubes in the zebrafish (Danio rerio) nervous system. Toxicology and Applied Pharmacology, v.280, n.3 p.484- 492 , 2014. Disponível em: <>. Acesso em 17 Jan 2016. pt_BR
dc.description.abstract Nanotechnology has been proven to be increasingly compatible with pharmacological and biomedical applications. Therefore, we evaluated the biological interactions of single-wall carbon nanotubes functionalized with polyethylene glycol (SWNT-PEG). For this purpose, we analyzed biochemical, histological, behavioral and biodistribution parameters to understand how this material behaves in vitro and in vivo using the fish Danio rerio (zebrafish) as a biological model. The in vitro results for fish brain homogenates indicated that SWNT-PEG had an effect on lipid peroxidation and GSH (reduced glutathione) content. However, after intraperitoneal exposure, SWNT-PEG proved to be less biocompatible and formed aggregates, suggesting that the PEG used for the nanoparticle functionalization was of an inappropriate size for maintaining product stability in a biological environment. This problem with functionalization may have contributed to the low or practically absent biodistribution of SWNT-PEG in zebrafish tissues, as verified by Raman spectroscopy. There was an accumulation of material in the abdominal cavity that led to inflammation and behavioral disturbances, as evaluated by a histological analysis and an open field test, respectively. These results provide evidence of a lack of biocompatibility of SWNTs modified with short chain PEGs, which leads to the accumulation of the material, tissue damage and behavioral alterations in the tested subjects pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access pt_BR
dc.subject SWNT-PEG pt_BR
dc.subject Biocompatibility pt_BR
dc.subject Biodistribution pt_BR
dc.subject Behavioral pt_BR
dc.subject Stress pt_BR
dc.subject Toxicity pt_BR
dc.subject Oxidative stress pt_BR
dc.title Biodistribution and toxicological study of PEGylated single-wall carbon nanotubes in the zebrafish (Danio rerio) nervous system pt_BR
dc.type article pt_BR
dc.identifier.doi 10.1016/j.taap.2014.08.018 · pt_BR

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