Show simple item record Silva, Naylê Maria Oliveira da Germano, Fabiana Nunes Vidales-Braz, Beatris Maria Zanella, Ricardo do Carmo Santos, Deise Machado dos Lobato, Rubens Caurio Martinez, Ana Maria Barral de 2016-11-16T14:45:46Z 2016-11-16T14:45:46Z 2015
dc.identifier.citation SILVA, Naylê Maria Oliveira da et al. Polymorphisms of IL-10 gene in patients infected with HCV under antiviral treatment in southern Brazil. Cytokine, v.73,n. 2, p. 253–257. Disponível em:<>. Acesso em: 15 nov. 2016. pt_BR
dc.identifier.issn 1043-4666
dc.description.abstract Interleukin-10 (IL-10) is a cytokine that plays an important role in the regulation of the immune system. Gene polymorphisms of IL-10 have been associated with the different expression levels of this cytokine. In hepatitis C virus infection, IL-10 appears to interfere with the progression of disease, viral persistence and the response to therapy. This study investigated genetic variability in the IL-10 gene promoter between patients infected with hepatitis C virus (HCV) and healthy individuals, associating the frequency of polymorphisms with different aspects of viral infection. This is a case-control study with 260 patients who were infected with HCV and 260 healthy individuals. Genotyping of the polymorphisms was performed using the technique of amplification refractory mutation system PCR (ARMS-PCR) for regions of the IL-10 gene promoter (-1082 G/A, -819 C/T, -592 C/A). The frequencies of alleles and genotypes related to polymorphisms in the IL-10 gene promoter showed a higher frequency of the G allele and genotype GG in the -1082 region between the infected group and the control group (p = 0.005 and p = 0.001, respectively), whereas the AA genotype was significantly more frequent in the control group. The frequencies of the haplotypes GTA and GCC were higher in the group of infected individuals, whereas the haplotype ATA was more frequent in the healthy group (p < 0.006). It was also observed that the genotypes GG and AG in the region -1082 were significantly more frequent among patients infected with HCV who were in advanced stages of fibrosis and cirrhosis (p = 0.042). No association was observed between polymorphisms of IL-10 and sustained virologic response (SVR). pt_BR
dc.language.iso eng pt_BR
dc.publisher Elsevier pt_BR
dc.rights open access pt_BR
dc.subject ARMS-PCR pt_BR
dc.subject HCV pt_BR
dc.subject IL-10 pt_BR
dc.subject Genotyping pt_BR
dc.subject Polymorphism pt_BR
dc.title Polymorphisms of IL-10 gene in patients infected with HCV under antiviral treatment in southern Brazil pt_BR
dc.type article pt_BR
dc.identifier.doi pt_BR

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