Show simple item record Sucupira, Maria Cecilia Araripe Munerato, Patricia Silveira, Jussara Maria Santos, André Felipe Andrade dos Janini, Luiz Mário Soares, Marcelo Alves Diaz, Ricardo Sobhie 2017-02-03T01:31:50Z 2017-02-03T01:31:50Z 2013
dc.identifier.citation SUCUPIRA, Maria Cecilia Araripe et al. Phenotypic Susceptibility to Antiretrovirals Among Clades C, F, and B/F Recombinant Antiretroviral-Naive HIV Type 1 Strains. AIDS Research and Human Retroviruses, v. 29, n. 6, p. 880-886, 2013. Disponível em: <>. Acesso em: 02 fev. 2017. pt_BR
dc.identifier.issn 0889-2229
dc.description.abstract To evaluate antiretroviral phenotypic susceptibility of wild-type HIV-1 strains circulating in Brazil, samples from antiretroviral-naïve individuals infected with subtypes C (n=16), F (n=9), or B/F (n=7), where reverse transcriptase is B and protease is F, were phenotyped using the AntivirogramTM Assay (Virco, Mechelen, Belgium). Reduced susceptibility to protease inhibitors (PIs) was observed in one C and three F isolates. None of these samples had any known PI resistance mutations. The Phenotypic Fold Change to one PI was above the biologic cut-off in 3 of 96 (3.1%) of clade F phenotypic determinations and 1 of 96 (1.0%) of C. Phenotypic resistance to at least one nucleoside reverse transcriptase inhibitor (NRTI) was found for two B/F, four C, and three F isolates. The Phenotypic Fold Change in susceptibility to NRTIs was above the cut-off value in 9 of 111 (8.1%) of clade C determinations, as compared to 3 of 63 (4.8%) for clade F and 2 of 49 (4.1%) for clade B. The Phenotypic Fold Change to non-NRTI (NNRTI) was above the cut-off in 7 of 32 (21.9%) of C isolates determinations, whereas none of the F isolates had decrease of susceptibility. Only two of the sixteen C samples had a known NNRTI resistance mutation. The NNRTI Fold Change was above the cut-off value in 3 of 14 (21.4%) of phenotypic determination of Brazilian B/F recombinants, representing clade B reverse transcriptase. NNRTI susceptibility should be better investigated in clade C and B/F recombinants. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.subject HIV-1 subtype pt_BR
dc.subject Phenotypic susceptibility pt_BR
dc.subject Antiretroviral naïve pt_BR
dc.subject Brazil pt_BR
dc.title Phenotypic Susceptibility to Antiretrovirals Among Clades C, F, and B/F Recombinant Antiretroviral-Naive HIV Type 1 Strains pt_BR
dc.type article pt_BR
dc.identifier.doi 10.1089/AID.2012.0259 pt_BR

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