dc.contributor.author |
Delviks-Frankenberry, Krista A. |
|
dc.contributor.author |
Lengruber, Renan Bohrer |
|
dc.contributor.author |
Santos, André Felipe Andrade dos |
|
dc.contributor.author |
Silveira, Jussara Maria |
|
dc.contributor.author |
Soares, Marcelo Alves |
|
dc.contributor.author |
Kearney, Mary Frances |
|
dc.contributor.author |
Maldarelli, Frank |
|
dc.contributor.author |
Pathak, Vinay Kumar |
|
dc.date.accessioned |
2017-02-03T16:07:57Z |
|
dc.date.available |
2017-02-03T16:07:57Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
DELVIKS-FRANKENBERRY, Krista et al. Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance. Virology, v. 435, n.2, p. 433-441, 2013. Disponível em: <http://www.sciencedirect.com/science/article/pii/S004268221200462X>. Acesso em: 02 fev. 2017. |
pt_BR |
dc.identifier.issn |
0042-6822 |
|
dc.identifier.uri |
http://repositorio.furg.br/handle/1/7054 |
|
dc.description.abstract |
Mutations in the connection subdomain (CN) and RNase H domain (RH) of HIV-1 reverse transcriptase
(RT) from subtype B-infected patients enhance nucleoside and nonnucleoside RT inhibitor (NRTI and
NNRTI) resistance by affecting the balance between polymerization and RNase H activity. To determine
whether CN mutations in subtype C influence drug sensitivity, single genome sequencing was
performed on Brazilian subtype C-infected patients failing RTI therapy. CN mutations identified were
similar to subtype B, including A376S, A400T, Q334D, G335D, N348I, and A371V, and increased AZT
resistance in the presence of thymidine analog mutations. CN mutations also enhanced NNRTI
resistance in the presence of classical NNRTI mutations: etravirine resistance was enhanced 6- to 11-
fold in the presence of L100I/K103N/Y181C. These results indicate that selection of CN mutations in
treatment-experienced patients also occurs in subtype-C-infected patients and are likely to provide
valuable information in predicting clinical RTI resistance. |
pt_BR |
dc.language.iso |
eng |
pt_BR |
dc.rights |
restrict access |
pt_BR |
dc.subject |
Subtype C |
pt_BR |
dc.subject |
Connection domain |
pt_BR |
dc.subject |
NRTI |
pt_BR |
dc.subject |
NNRTI |
pt_BR |
dc.subject |
Drug resistance |
pt_BR |
dc.title |
Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance |
pt_BR |
dc.type |
article |
pt_BR |
dc.identifier.doi |
http://dx.doi.org/10.1016/j.virol.2012.09.021 |
pt_BR |