dc.contributor.author |
Gasparotto, Aline Simas |
|
dc.contributor.author |
Sprinz, Eduardo |
|
dc.contributor.author |
Lazzaretti, Rosmeri Kuhmmer |
|
dc.contributor.author |
Kuhmmer, Regina |
|
dc.contributor.author |
Silveira, Jussara Maria |
|
dc.contributor.author |
Basso, Rossana Patricia |
|
dc.contributor.author |
Pinheiro, Cezar Arthur Tavares |
|
dc.contributor.author |
Silveira, Mariângela Freitas da |
|
dc.contributor.author |
Ribeiro, Jorge Pinto |
|
dc.contributor.author |
Mattevi, Vanessa Suñé |
|
dc.date.accessioned |
2017-02-04T17:03:06Z |
|
dc.date.available |
2017-02-04T17:03:06Z |
|
dc.date.issued |
2012 |
|
dc.identifier.citation |
GASPAROTTO, Aline Simas et al. Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART. AIDS, v. 26, n.1, p.19–26, 2012. Disponível em: < http://journals.lww.com/aidsonline/pages/articleviewer.aspx?year=2012&issue=01020&article=00003&type=abstract >. Acesso em: 03 fev. 2017. |
pt_BR |
dc.identifier.issn |
0269-9370 |
|
dc.identifier.uri |
http://repositorio.furg.br/handle/1/7057 |
|
dc.description.abstract |
Objective: To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen
receptor-a (ERa) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERb
(ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse
effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in
their prevalence between sexes in HIV-infected individuals on HAART.
Design: Cross-sectional study.
Methods: Blood samples and anthropometric measurements were collected from 614
patients at reference services in the cities of Porto Alegre, Pelotas and Rio Grande in
Brazil. The SNPs were genotyped by real-time PCR.
Results: The lipodystrophy subtype frequencies in patients of different sexes showed
statistically significant differences; the atrophic pattern was more prevalent in men, and
the hypertrophic pattern was more prevalent in women. Furthermore, metabolic
syndrome prevalence was higher in women than in men. The ESR1 rs2813544
G-allele was associated with higher measurements of several anthropometric variables
in women: BMI, total subcutaneous fat and subcutaneous fat of limbs. Additionally,
patients who were AA homozygous for ESR2 rs3020450 presented an increased risk for
developing lipoatrophy (prevalence ratio 1.37, 95% confidence interval 1.09–1.73,
P ¼ 0.007).
Conclusion: Significant differences in lipodystrophy and metabolic syndrome prevalence
were detected between sexes. Moreover, the ESR1 gene (rs2813544) presented
significant sex-specific associations with anthropometric variables, and the ESR2 gene
(rs3020450) was associated with an increased risk of developing lipoatrophy. Our
results suggest that these genes are in part responsible for the sexual dimorphism in fat
tissue redistribution and patterns of lipodystrophy. |
pt_BR |
dc.language.iso |
eng |
pt_BR |
dc.rights |
open access |
pt_BR |
dc.subject |
Dyslipidemia |
pt_BR |
dc.subject |
Estrogen receptor-a |
pt_BR |
dc.subject |
Estrogen receptor-b |
pt_BR |
dc.subject |
HAART |
pt_BR |
dc.subject |
Lipodystrophy |
pt_BR |
dc.title |
Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART |
pt_BR |
dc.type |
article |
pt_BR |
dc.identifier.doi |
10.1097/QAD.0b013e32834db3ac |
pt_BR |