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dc.contributor.author Vianna, Júlia Silveira
dc.contributor.author Ramis, Ivy Bastos
dc.contributor.author Halicki, Priscila Cristina Bartolomeu
dc.contributor.author Gastal, Otavio Leite
dc.contributor.author Silva, Renato Azevedo
dc.contributor.author Salomão Junior, José
dc.contributor.author Santos, Deise Machado dos
dc.contributor.author Chaves, Ana Lúcia Hentsch
dc.contributor.author Juliano, Carlos Renan Varela
dc.contributor.author Jannke, Heitor Alberto
dc.contributor.author Silva Júnior, Lande Vieira da
dc.contributor.author Groll, Andrea Von
dc.contributor.author Silva, Pedro Eduardo Almeida da
dc.date.accessioned 2017-03-27T17:28:46Z
dc.date.available 2017-03-27T17:28:46Z
dc.date.issued 2015
dc.identifier.citation VIANNA, Júlia Silveira et al. Detection of helicobacter pylori CagA EPIYA in gastric biopsy specimens and its relation to gastric diseases. Diagnostic Microbiology and Infectious Disease. v. 83, p. 89–92, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0732889315002035 >. Acesso em: 23 mar. 2017. pt_BR
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.furg.br/handle/1/7114
dc.description.abstract CagA of Helicobacter pylori undergoes tyrosine phosphorylation in a region containing differing numbers of repeat sequences (EPIYAs), which can result in a modulation of the inflammatory response. This study investigated whether the presence of CagA EPIYA variations in strains of H. pylori that are positive for this region contributes to differing degrees of disease severity in the gastric mucosa. In this study, 157 H. pylori–positive patients were included, and of those, 40.8% (64/157) were infected with cagA-positive strains, which were assayed for the presence of CagA EPIYA-ABC, EPIYA-ABCC, and EPIYA-ABCCC. Peptic ulcers were significantly more prevalent in patients infected with strains containing CagA EPIYA-ABCC/ABCCC than in those with CagA EPIYA ABC strains (P = 0.044). This suggests that the number of repetitions of EPIYA-C influences the development of gastroduodenal lesions, highlighting the importance and usefulness of evaluating the cagA gene sequence when making therapeutic intervention decisions in patients infected with H. pylori. pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access pt_BR
dc.subject Helicobacter pylori pt_BR
dc.subject CagA protein pt_BR
dc.subject Amino acid repeat sequence pt_BR
dc.subject Gastritis pt_BR
dc.subject Peptic ulcer pt_BR
dc.title Detection of helicobacter pylori CagA EPIYA in gastric biopsy specimens and its relation to gastric diseases pt_BR
dc.type article pt_BR
dc.identifier.doi http://dx.doi.org/10.1016/j.diagmicrobio.2015.05.017 pt_BR


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