Show simple item record Hädrich, Gabriela Vaz, Gustavo Richter Maidana, Michelle Kratz, Jadel Müller Neckel, Gecioni Loch Favarin, Daniely Cornélio Rogerio, Alexandre de Paula Silva Júnior, Flávio Manoel Rodrigues da Baisch, Ana Luiza Muccillo Dora, Cristiana Lima 2017-07-17T21:26:53Z 2017-07-17T21:26:53Z 2015
dc.identifier.citation HÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:<>. Acesso em: 31 mar. 2017. pt_BR
dc.identifier.issn 0724-8741
dc.description.abstract Purpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.subject Anti-oedematous activity pt_BR
dc.subject Antioxidant pt_BR
dc.subject Inflammation pt_BR
dc.subject Lipid nanocarriers pt_BR
dc.subject Quercetin pt_BR
dc.subject Toxicity pt_BR
dc.title Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats pt_BR
dc.type article pt_BR
dc.identifier.doi 10.1007/s11095-015-1844-6 pt_BR

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