Show simple item record Martins, Daiane Carrion, Lillian Lucas Soares, Daniela Fernandes Ramos Salomé, Kahlil Schwanka Silva, Pedro Eduardo Almeida da Barison, Andersson Nunez, Cecilia Veronica 2017-07-19T18:29:26Z 2017-07-19T18:29:26Z 2013
dc.identifier.citation MARTINS, Daiane et al. Triterpenes and the Antimycobacterial Activity of Duroia macrophylla Huber (Rubiaceae). Journal of Biomedicine and Biotechnology, v. 2013, p. 1-7, 2013. Disponível em:<>. Acesso 08 abr. 2017. pt_BR
dc.identifier.issn 2314-6133
dc.description.abstract Duroia macrophylla popularly known as “cabec¸a-de-urubu,” “apuru ´ ´ı,” or “puru´ı-grande-da-mata” occurs in the Amazon Forest. Its leaves and branches were collected twice and extracted with dichloromethane and methanol. All extracts were subjected to phytochemical investigation and terpenes and flavonoids were found in all dichloromethane and methanol extracts, respectively. Methanol extracts from both branches (1st collection) and leaves (2nd collection) presented hydrolyzed tannins, yet alkaloids were only detected in the dichloromethane and methanol extracts from branches at the 2nd collection. Phenol compounds were found in both dichloromethane extracts’ collections. The action of every extract was assayed against Mycobacterium tuberculosis (RMPr, H37Rv, and INHr strains), showing that the dichloromethane extract from leaves (1st collection) has the major biological activity, with a MIC of 6.25 𝜇��g/mL for the INHr strain, 25.0 𝜇��g/mL for the RMPr strain, and ≤6.25 𝜇��g/mL for the H37Rv strain. The chromatographic fractioning of the dichloromethane extract from leaves (1st collection) yielded the isolation of two triterpenes: oleanolic and ursolic acids, which were identified by NMR analysis and reported for the first time in the Duroia genus. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.title Triterpenes and the Antimycobacterial Activity of Duroia macrophylla Huber (Rubiaceae) pt_BR
dc.type article pt_BR
dc.identifier.doi pt_BR

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