Show simple item record Bosco, Lidiane Dal Weber, Gisele Eva Bruch Parfitt, Gustavo Morrone Cordeiro, Arthur Sahoo, Sangram Leite, Cristiano Fantini Klosterhoff, Marta da Costa Romano, Luis Alberto Furtado, Clascidia Aparecida Santos, Adelina Pinheiro Monserrat, José María Barros, Daniela Marti 2017-07-19T18:33:55Z 2017-07-19T18:33:55Z 2015
dc.identifier.citation BOSCO, Lidiane Dal et al. Biopersistence of PEGylated Carbon Nanotubes Promotes a Delayed Antioxidant Response after Infusion into the Rat Hippocampus. Plos One, v. 10, p. 1-17, 2015. Disponível em:<>. Acesso em: 02 maio 2017. pt_BR
dc.identifier.issn 1932-6203
dc.description.abstract Carbon nanotubes are promising nanomaterials for the diagnosis and treatment of brain disorders. However, the ability of these nanomaterials to cross cell membranes and interact with neural cells brings the need for the assessment of their potential adverse effects on the nervous system. This study aimed to investigate the biopersistence of single-walled carbon nanotubes functionalized with polyethylene glycol (SWCNT-PEG) directly infused into the rat hippocampus. Contextual fear conditioning, Y-maze and open field tasks were performed to evaluate the effects of SWCNT-PEG on memory and locomotor activity. The effects of SWCNT-PEG on oxidative stress and morphology of the hippocampus were assessed 1 and 7 days after infusion of the dispersions at 0.5, 1.0 and 2.1 mg/mL. Raman analysis of the hippocampal homogenates indicates the biopersistence of SWCNT-PEG in the hippocampus 7 days post-injection. The infusion of the dispersions had no effect on the acquisition or persistence of the contextual fear memory; likewise, the spatial recognition memory and locomotor activity were not affected by SWCNT-PEG. Histological examination revealed no remarkable morphological alterations after nanomaterial exposure. One day after the infusion, SWCNT-PEG dispersions at 0.5 and 1.0 mg/mL were able to decrease total antioxidant capacity without modifying the levels of reactive oxygen species or lipid hydroperoxides in the hippocampus. Moreover, SWCNT-PEG dispersions at all concentrations induced antioxidant defenses and reduced reactive oxygen species production in the hippocampus at 7 days post-injection. In this work, we found a time-dependent change in antioxidant defenses after the exposure to SWCNT-PEG. We hypothesized that the persistence of the nanomaterial in the tissue can induce an antioxidant response thatmight have provided resistance to an initial insult. Such antioxidant delayed response may constitute an adaptive response to the biopersistence of SWCNT-PEG in the hippocampus. pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.title Biopersistence of PEGylated Carbon Nanotubes Promotes a Delayed Antioxidant Response after Infusion into the Rat Hippocampus pt_BR
dc.type article pt_BR
dc.identifier.doi pt_BR

Files in this item

This item appears in the following Collection(s)


  • FAMED – Artigos publicados em periódicos
  • Show simple item record