Lopes, Carolina RosaD'Oca, Caroline Da Ros MontesDuarte, Rodrigo da CostaKurz, Márcia Helena SchererPrimel, Ednei GilbertoClementin, Rosilene MariaVillarreyes, Joaquín Ariel MorónD'Oca, Marcelo Gonçalves Montes2011-12-292011-12-292010LOPES, Carolina Rosa et al. Síntese de novas amidas graxas a partir da aminólise de ésteres metílicos. Química Nova, São Paulo, v. 33, n. 6, p. 1335-1341, 2010. Disponível em: <http://www.scielo.br/pdf/qn/v33n6/22.pdf> Acesso em: 29 dez. 2011.0100-4042http://repositorio.furg.br/handle/1/1653Recent biochemical and pharmacological studies have led to the characterization of different fatty acid amides as a new family of biologically active lipids. Here, we describe the synthesis of new amides from C16:0, 18:0, 18:1 and 18:1, OH fatty acids (FFA) families with cyclic and acyclic amines and demonstrate for the first time that these compounds produce citotoxic effects. Application of this method to the synthesis of fatty acid amides was performed using the esters aminolysis as a key step and various carboxylic amides were prepared in good yield from fatty acid methyl esters (FAMEs).poropen accessAnandamideRicinoleic amidesFAMEsarticle