Molecular basis of pathogenicity in helicobacter pylori clinical isolates
Ramis, Ivy Bastos; Fonseca, Tesiê Leopoldo; Moraes, Ernani Pinho de; Fernandes, Márcia Silveira; Sassi, Raul Andrés Mendonza; Rodrigues, Obirajara; Juliano, Carlos Renan Varela; Scaini, Carlos James; Silva, Pedro Eduardo Almeida da
Abstract:
This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.