Preparative Isolation of Antimycobacterial Shoreic Acid from Cabralea canjerana by High Speed Countercurrent Chromatography
Leitão, Gilda Guimarães; Abreu, Lisandra Ferreira de; Costa, Fernanda das Neves; Brum, Thiago Braga; Soares, Daniela Fernandes Ramos; Silva, Pedro Eduardo Almeida da; Lourenço, Maria Cristina da Silva; Leitão, Suzana Guimarães
Abstract:
High speed countercurrent chromatography (HSCCC) was used to isolate the dammarane type triterpene shoreic acid from the dichloromethane extract of leaves of Cabralea canjerana, which showed activity against Mycobacterium tuberculosis. A preparative scale-up of the process was also developed.