Navegando por Autor "Russowsky, Dennis"

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Electrochemical Oxidation of N - p -Toluenesulfinamides
(2002) D'Oca, Marcelo Gonçalves Montes; Russowsky, Dennis; Canto, Karen Fabiano Santos do; Gressler, Tanara; Gonçalves, Reinaldo Simões
Contrasting and interesting electrochemical behavior is observed in anodic oxidation of N-substituted p-toluenesulfinamides under controlled current conditions. For sulfinamides derived from secondary alkylamines and primary arylamines, the N-sulfinyl group is removed and the corresponding amines are formed; for sulfinamides derived from primary alkylamines, sulfur oxidation yields the corresponding sulfonamides in good yields.
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Multicomponent biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O
(Communication, 2004) Russowsky, Dennis; Lopes, Fabricio Abella; Silva, Victor da; Canto, Karen Fabiano Santos do; D'Oca, Marcelo Gonçalves Montes; Godoi, Marla Narciso Biajoli
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H2O, NiCl2.6H2O and CoCl2.6H2O which were used with HCl as co-catalyst. The synthesis of 3,4-dihydropyrimidinones was achieved in good to excelent yields.
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Multicomponent Biginelli’s Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Promoted by SnCl2.2H2O
(Sociedade Brasileira de Química, 2004) Russowsky, Dennis; Lopes, Fabricio Abella; Silva, Victor da; Canto, Karen Fabiano Santos do; D'Oca, Marcelo Gonçalves Montes; Godoi, Marla Narciso Biajoli
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H2O, NiCl2.6H2O and CoCl2.6H2O which were used with HCl as co-catalyst. The synthesis of 3,4- dihydropyrimidinones was achieved in good to excelent yields.
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Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids
(Elsevier, 2013) Rodrigues, Marieli Oliveira; Cantos, Jéssica Borges; D'Oca, Caroline Da Ros Montes; Soares, Karina Lotz; Coelho, Tatiane Silveira; Piovesan, Luciana Almeida; Russowsky, Dennis; Silva, Pedro Eduardo Almeida da; D'Oca, Marcelo Gonçalves Montes
This work describes the synthesis of a series of fatty acid hydrazide derivatives of isoniazid (INH). The compounds were tested against Mycobacterium tuberculosis H37Rv (ATCC 27294) as well as INH-resistant (ATCC 35822 and 1896 HF) and rifampicin-resistant (ATCC 35338) M. tuberculosis strains. The fatty acid derivatives of INH showed high antimycobacterial potency against the studied strains, which is desirable for a pharmaceutical compound, suggesting that the increased lipophilicity of isoniazid plays an important role in its antimycobacterial activity.
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Synthesis and differential antiproliferative activity of Biginelli compounds against cancer cell lines: Monastrol, oxo-monastrol and oxygenated analogues
(Elsevier, 2006) Russowsky, Dennis; Canto, Rômulo Faria Santos; Sanches, Sérgio Augusto Antunes; D'Oca, Marcelo Gonçalves Montes; Fátima, Ângelo de; Pilli, Ronaldo Aloise; Kohn, Luciana Konecny; Antônio, Márcia Aparecida; Carvalho, João Ernesto de
The synthesis and differential antiproliferative activity of monastrol (1a), oxo-monastrol (1b) and eight oxygenated derivatives 3a,b–6a,b on seven human cancer cell lines are described. For all evaluated cell lines, monastrol (1a) was shown to be more active than its oxo-analogue, except for HT-29 cell line, suggesting the importance of the sulfur atom for the antiproliferative activity. Monastrol (1a) and the thio-derivatives 3a, 4a and 6a displayed relevant antiproliferative properties with 3,4-methylenedioxy derivative 6a being approximately more than 30 times more potent than monastrol (1a) against colon cancer (HT-29) cell line.