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dc.contributor.author Marques, Daiane
dc.contributor.author Sandrini, Juliana Zomer
dc.contributor.author Boyle, Robert Tew
dc.contributor.author Marins, Luis Fernando Fernandes
dc.contributor.author Trindade, Gilma Santos
dc.date.accessioned 2011-11-17T06:40:43Z
dc.date.available 2011-11-17T06:40:43Z
dc.date.issued 2009
dc.identifier.citation MARQUES, D. S. et al. Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines. Leukemia Research , v. 34, p. 757-762, 2010. Disponível em: <http://www.inct-ta.furg.br/english/producao/262010.pdf>. Acesso em: 03 nov. 2011. pt_BR
dc.identifier.issn 0145-2126
dc.identifier.uri http://repositorio.furg.br/handle/1/1353
dc.description.abstract The K562 cell line (chronic myeloid leukemia), sensitive to chemotherapy (non-MDR), and the Lucena cell line, resistant to chemotherapy (MDR) were investigated. The results suggest that both cell lines possess CD34 + CD38 − profiles of hematopoietic stem cell markers. The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor,which is also considered a marker of tumor stem cells. Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells. pt_BR
dc.language.iso eng pt_BR
dc.rights restrict access pt_BR
dc.subject CML pt_BR
dc.subject CD34 pt_BR
dc.subject CD38 pt_BR
dc.subject Oct-4 pt_BR
dc.subject ABCB1 pt_BR
dc.subject ABCG2 pt_BR
dc.subject ABCC1 pt_BR
dc.title Relationship between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines pt_BR
dc.type article pt_BR


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