Síntese de novas amidas graxas a partir da aminólise de ésteres metílicos
Lopes, Carolina Rosa; D'Oca, Caroline Da Ros Montes; Duarte, Rodrigo da Costa; Kurz, Márcia Helena Scherer; Primel, Ednei Gilberto; Clementin, Rosilene Maria; Villarreyes, Joaquín Ariel Morón; D'Oca, Marcelo Gonçalves Montes
Abstract:
Recent biochemical and pharmacological studies have led to the characterization of different fatty acid amides as a new family of biologically active lipids. Here, we describe the synthesis of new amides from C16:0, 18:0, 18:1 and 18:1, OH fatty acids (FFA) families with cyclic and acyclic amines and demonstrate for the first time that these compounds produce citotoxic effects. Application of this method to the synthesis of fatty acid amides was performed using the esters aminolysis as a key step and various carboxylic amides were prepared in good yield from fatty acid methyl esters (FAMEs).