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Browsing FAMED – Faculdade de Medicina by Author "Portaels, Françoise"

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Fitness of Mycobacterium tuberculosis strains of the W-Beijing and Non-W-Beijing genotype

Groll, Andrea Von; Martin, Anandi; Stehr, Matthias; Singh, Mahavir; Portaels, Françoise; Silva, Pedro Eduardo Almeida da; Palomino, Juan Carlos (2010)

Background: Multidrug resistant tuberculosis (MDR-TB) is a major threat for global tuberculosis control. The W-Beijing Mycobacterium tuberculosis genotype has been associated with drug resistance. Elucidation of the ...
Fitness study of the RDRio lineage and LAM family of mycobacterium tuberculosis in the city of Rio Grande, Brazil

Groll, Andrea Von; Martin, Anandi; Felix, Carolina Rodrigues; Prata, Pedro Fernandes Sanmartin; Honscha, Gunther; Portaels, Françoise; Vandamme, Peter; Silva, Pedro Eduardo Almeida da; Palomino, Juan Carlos (2010)

RDRio is a novel Mycobacterium tuberculosis lineage of the Latin American– Mediterranean (LAM) family. LAM has been found worldwide but is more predominant in South America. The aim of this study was to assess the presence ...
Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb

Groll, Andrea Von; Martin, Anandi; Jureen, Pontus; Hoffner, Sven; Vandamme, Peter; Portaels, Françoise; Palomino, Juan Carlos; Silva, Pedro Almeida da (2009)

This study evaluated cross-resistance of Mycobacterium tuberculosis strains to oﬂoxacin, moxiﬂoxacin, and gatiﬂoxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were ...
Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb

Groll, Andrea Von; Martin, Anandi; Jureen, Pontus; Hoffner, Sven; Vandamme, Peter; Portaels, Françoise; Palomino, Juan Carlos; Silva, Pedro Eduardo Almeida da (2009)

This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were ...
Growth kinetics of mycobacterium tuberculosis measured by quantitative resazurin reduction assay: a tool for fitness studies

Groll, Andrea Von; Martin, Anandi; Portaels, Françoise; Silva, Pedro Eduardo Almeida da; Palomino, Juan Carlos (2010)

We standardized a method to evaluate the growth kinetics of Mycobacterium tuberculosis by measuring quantitatively the reduction of resazurin by spectrophotometry. Growth curves and the rate of growth of twenty-one M. ...
Nitrate reductase assay for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide

Martin, Anandi; Cubillos-Ruiz, Andrés; Groll, Andrea Von; Portillo, Patricia Del; Portaels, Françoise; Palomino, Juan Carlos (2008)

Objectives: The purpose of this study was to develop the nitrate reductase assay (NRA) for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide resistance as a marker of ...
Rapid detection of mycobacterium tuberculosis resistance to second-line drugs by use of the manual mycobacterium growth indicator tube system

Martin, Anandi; Groll, Andrea Von; Fissette, Krista; Palomino, Juan Carlos; Varaine, Francis; Portaels, Françoise (2008)

The objective of this study was to evaluate the manual mycobacterium growth indicator tube (MGIT) system for the testing of Mycobacterium tuberculosis susceptibility to second-line drugs compared to the proportion method. ...

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