Objective: To identify a new circulating recombinant form (CRF) of HIV-1 comprising two circulating subtypes in the southern region in Brazil, subtypes B and C. Methods: A total of 152 HIV-positive patients followed at ...

Mutations in the connection subdomain (CN) and RNase H domain (RH) of HIV-1 reverse transcriptase (RT) from subtype B-infected patients enhance nucleoside and nonnucleoside RT inhibitor (NRTI and NNRTI) resistance by ...

Background: Although extensive HIV drug resistance information is available for the first 400 amino acids of its reverse transcriptase, the impact of antiretroviral treatment in C-terminal domains of Pol (thumb, connection ...

Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immuno- logical and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but ...

Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunological and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but few ...

Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency ...

Background: To evaluate the impact of HIV-1 CRF31_BC in the southern Brazilian HIV epidemic. Methods: Blood plasma from 284 patients was collected from July 2002 to January 2003 at 2 reference HIV/AIDS centers in ...

Objective: TLRs (toll-like receptors) and RLRs (RIG-I-like receptors) mediate innate immune responses by detecting microorganism invasion. RIG-I activation results in the production of interferon (IFN) type 1 and IFN ...

Objective: TLRs (toll-like receptors) and RLRs (RIG-I-like receptors) mediate innate immune responses by detecting microorganism invasion. RIG-I activation results in the production of interferon (IFN) type 1 and IFN ...

This study evaluated the impact of 9 single nucleotide polymorphisms (SNPs) in 6 candidate genes (APOB, APOA5, APOE, APOC3, SCAP, and LDLR) over dyslipidemia in HIV-infected patients on stable antiretroviral therapy (ART) ...

Objective: To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-a (ERa) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERb (ESR2, rs3020450, rs7154455 and rs4986938) genes and ...

Background: Human immunodeficiency virus type 1 (HIV-1) subtype B predominates in Brazil, but in the southern region subtype C is the most frequent, followed by subtypes B, F1 and recombinant forms. In southern Brazil, ...

Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross-sectional study was conducted from September ...

The aim of this study was to determine the rate and risk factors of HIV-1 mother-to-child transmission (MTCT), the timing of transmission and the transmitted subtype in a population where subtypes B and C co-circulates. ...

We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS ...

To evaluate antiretroviral phenotypic susceptibility of wild-type HIV-1 strains circulating in Brazil, samples from antiretroviral-naïve individuals infected with subtypes C (n=16), F (n=9), or B/F (n=7), where reverse ...

Objective: In view of the relevance of co-infection with tuberculosis and human immunodeficiency virus, this study was designed to determine tuberculosis prevalence and identify factors related to tuberculosis in patients ...

Previous studies have demonstrated that coinfection with HPgV is a protective factor for human immunodeficiency virus (HIV)-infected patients, leading to slower disease progression, and longer survival after established ...

Objetivo: Considerando a relevância da co-infecção vírus da imunodeficiência humana/tuberculose, este estudo foi desenvolvido para determinar a prevalência e os fatores associados à tuberculose em pacientes residentes em ...

The aim of the study was to assess the prevalence of oral lesions in AIDS patients and identify associated factors. A cross-sectional study collected data from interviews, clinical examination, and a review of medical ...