Show simple item record Garcia, Michele Carrett Dias Votto, Ana Paula de Souza Filgueira, Daza de Moraes Vaz Batista Almeida, Daniela Volcan Vallochi, Adriana Lima D'Oca, Marcelo Gonçalves Montes Marins, Luis Fernando Fernandes Trindade, Gilma Santos 2015-05-14T20:22:35Z 2015-05-14T20:22:35Z 2011
dc.identifier.citation CARRETT-DIAS, Michele et al. Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells. Bioscience Reports, v. 31 n. 5, p. 391-398, 2011. Disponível em: <>. Acesso em 07 mai. 2015 pt_BR
dc.identifier.issn 1573-4935
dc.description.abstract ASA (acetylsalicylic acid) is an NSAID (non-steroidal anti-inflammatory drug). ASA has gained attention as a potential chemopreventive and chemotherapeutic agent for several neoplasms. The aim of this study was to analyse the possible antitumoural effects of ASA in two erythroleukaemic cell lines, with or without the MDR (multidrug resistance) phenotype. The mechanism of action of different concentrations of ASA were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and necrosis, intracellular ROS (reactive oxygen species) formation and bcl-2, p53 and cox-2 gene expression. ASA inhibited the cellular proliferation or induced toxicity in K562 and Lucena cell lines, irrespective of the MDR phenotype. The ASA treatment provoked death by apoptosis and necrosis in K562 cells and only by necrosis in Lucena cells. ASA also showed antioxidant activity in both cell lines. The bcl-2, p53 and cox-2 genes in both cell lines treated with ASA seem to exhibit different patterns of expression. However, normal lymphocytes treated with the same ASA concentrations were more resistant than tumoral cells. The results of this work show that both cell lines responded to treatment with ASA, demonstrating a possible antitumoral and anti-MDR role for this drug pt_BR
dc.language.iso eng pt_BR
dc.rights open access pt_BR
dc.subject Acetylsalicylic acid (ASA) pt_BR
dc.subject Antioxidant pt_BR
dc.subject Death cell pt_BR
dc.subject Gene expression pt_BR
dc.subject Leukaemia pt_BR
dc.subject Multidrug resistance (MDR) pt_BR
dc.title Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells pt_BR
dc.type article pt_BR
dc.identifier.doi 10.1042/BSR20100115 pt_BR

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