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dc.contributor.author Rodrigues, Marieli Oliveira
dc.contributor.author Cantos, Jéssica Borges
dc.contributor.author D'Oca, Caroline Da Ros Montes
dc.contributor.author Soares, Karina Lotz
dc.contributor.author Coelho, Tatiane Silveira
dc.contributor.author Piovesan, Luciana Almeida
dc.contributor.author Russowsky, Dennis
dc.contributor.author Silva, Pedro Eduardo Almeida da
dc.contributor.author D'Oca, Marcelo Gonçalves Montes
dc.date.accessioned 2016-10-14T18:22:44Z
dc.date.available 2016-10-14T18:22:44Z
dc.date.issued 2013
dc.identifier.citation RODRIGUES, Marieli Oliveira et al. Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids. Bioorganic & Medicinal Chemistry, v. 21, n. 22, p. 6910–6914, 2013. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089613008146?via=ihub>. Acesso em: 26 ago. 2014. pt_BR
dc.identifier.issn 0968-0896
dc.identifier.uri http://repositorio.furg.br/handle/1/6629
dc.description.abstract This work describes the synthesis of a series of fatty acid hydrazide derivatives of isoniazid (INH). The compounds were tested against Mycobacterium tuberculosis H37Rv (ATCC 27294) as well as INH-resistant (ATCC 35822 and 1896 HF) and rifampicin-resistant (ATCC 35338) M. tuberculosis strains. The fatty acid derivatives of INH showed high antimycobacterial potency against the studied strains, which is desirable for a pharmaceutical compound, suggesting that the increased lipophilicity of isoniazid plays an important role in its antimycobacterial activity. pt_BR
dc.language.iso eng pt_BR
dc.publisher Elsevier pt_BR
dc.rights restrict access pt_BR
dc.subject Fatty acids pt_BR
dc.subject Mycobacterium tuberculosis pt_BR
dc.subject INH-derivatives pt_BR
dc.subject Antimycobacterial activity pt_BR
dc.title Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids pt_BR
dc.type article pt_BR
dc.identifier.doi http://dx.doi.org/10.1016/j.bmc.2013.09.034 pt_BR


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