Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids
| dc.contributor.author | Rodrigues, Marieli Oliveira | |
| dc.contributor.author | Cantos, Jéssica Borges | |
| dc.contributor.author | D'Oca, Caroline Da Ros Montes | |
| dc.contributor.author | Soares, Karina Lotz | |
| dc.contributor.author | Coelho, Tatiane Silveira | |
| dc.contributor.author | Piovesan, Luciana Almeida | |
| dc.contributor.author | Russowsky, Dennis | |
| dc.contributor.author | Silva, Pedro Eduardo Almeida da | |
| dc.contributor.author | D'Oca, Marcelo Gonçalves Montes | |
| dc.date.accessioned | 2016-10-14T18:22:44Z | |
| dc.date.available | 2016-10-14T18:22:44Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | This work describes the synthesis of a series of fatty acid hydrazide derivatives of isoniazid (INH). The compounds were tested against Mycobacterium tuberculosis H37Rv (ATCC 27294) as well as INH-resistant (ATCC 35822 and 1896 HF) and rifampicin-resistant (ATCC 35338) M. tuberculosis strains. The fatty acid derivatives of INH showed high antimycobacterial potency against the studied strains, which is desirable for a pharmaceutical compound, suggesting that the increased lipophilicity of isoniazid plays an important role in its antimycobacterial activity. | pt_BR |
| dc.identifier.citation | RODRIGUES, Marieli Oliveira et al. Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids. Bioorganic & Medicinal Chemistry, v. 21, n. 22, p. 6910–6914, 2013. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089613008146?via=ihub>. Acesso em: 26 ago. 2014. | pt_BR |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.bmc.2013.09.034 | pt_BR |
| dc.identifier.issn | 0968-0896 | |
| dc.identifier.uri | http://repositorio.furg.br/handle/1/6629 | |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Elsevier | pt_BR |
| dc.rights | restrict access | pt_BR |
| dc.subject | Fatty acids | pt_BR |
| dc.subject | Mycobacterium tuberculosis | pt_BR |
| dc.subject | INH-derivatives | pt_BR |
| dc.subject | Antimycobacterial activity | pt_BR |
| dc.title | Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids | pt_BR |
| dc.type | article | pt_BR |